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The Power of DPA

Seal Oil is with mother’s milk one of the rare natural source of DPA. Although DPA, EPA and DHA work together to ensure the proper functioning of the human body, scientific research has shown that DPA has unique advantages.

  • Supports cardiovascular health
  • Enhances mental & cognitive health
  • Fights inflammation
  • Boosts immune system
  • Fetal & infant development
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  • Supports cardiovascular health
  • Enhances mental & cognitive health
  • Fights inflammation
  • Boosts immune system
  • Fetal & infant development

What is DPA?

Docosapentaenoic acid (DPA) is an essential fatty acid, shown to reduce blood clotting aortic plaque build-up Kaur G, Cameron-Smith D, Garg M, Sinclair AJ. Docosapentaenoic acid (22:5n-3): a review of its biological effects. Prog Lipid Res. 2011 Jan;50(1):28-34. doi: 10.1016/j.plipres.2010.07.004. Epub 2010 Jul 23. PMID: 20655949., and inflammation, and improve neural health. It also interacts powerfully with DHA and EPA—two other key omega-3 essential fatty acids—enabling the body to better store, absorb, and use those crucial molecules.Byelashov, O. A., Sinclair, A. J., & Kaur, G. (2015). Dietary sources, current intakes, and nutritional role of omega-3 docosapentaenoic acid. Lipid technology, 27(4), 79–82. https://doi.org/10.1002/lite.201500013

 

To get technical for a moment, DPA is a straight chain 22:5 polyunsaturated fatty acid (22 carbons, 5 double-bonds). It is found in oily fish, seafood, and beef in small quantities. Seal oil and breast milk, however, are rich in DPA. And that’s one key advantage seal oil supplements have over fish oil.

 

DPA is so valuable, in fact, a scientific research suggests the historically low rate of heart disease among northern Inuit populations is a direct result of the consumption of seal meat and blubber.Byelashov, O. A., Sinclair, A. J., & Kaur, G. (2015). Dietary sources, current intakes, and nutritional role of omega-3 docosapentaenoic acid. Lipid technology, 27(4), 79–82. https://doi.org/10.1002/lite.201500013

DPA vs. DHA vs. EPA

While their chemical structures differ, DPA (Docosapentaenoic acid), EPA (Eicosapentaenoic Acid) and DHA (Docosahexaenoic Acid) are all essential polyunsaturated omega-3 fatty acids. They are termed essential because the human body needs them to function optimally—but the human body is not capable of producing sufficient amounts on its own. That means we have to access these nutrients through food or supplements.

 

These three omega-3 fatty acids work together to support the healthy functioning of our bodies, boosting heart health, joint health, brain health, and immune system function. As well, each has a specific role to play:

DPA

  • Repairs damaged vessels
  • Fights chronic inflammation
  • Improves lipid metabolism
  • Boosts absorption of EPA and DHA

 

DHA

  • Boosts brain function
  • Helps combat mood disorders
  • Improves ocular health
  • Important component of cell membrane structure

EPA

  • Supports cardiovascular health
  • Supports immune system function
  • Reduces joint inflammation
  • Lowers cholesterol
Plan de travail 1

An Omega-3 that absorbs better

DPA, DHA, and EPA are assimilated and used differently by the body. A study by Mann et al. (2010) took a look at this. Participants were given seal oil, fish oil, or corn oil (placebo) for 14 days, at which point blood platelet levels were tested. The research indicated that seal oil raised platelet levels of DHA, DPA, and EPA—fish oil only resulted in elevated DHA levels.Mann NJ, O’Connell SL, Baldwin KM, Singh I, Meyer BJ. Effects of seal oil and tuna-fish oil on platelet parameters and plasma lipid levels in healthy subjects. Lipids. 2010 Aug;45(8):669-81. doi: 10.1007/s11745-010-3450-z. Epub 2010 Jul 23. PMID: 20652432Total omega-3 polyunsaturated fatty acid levels increased by 63% in participants who consumed seal oil; those who took fish oil demonstrated an increase of 41%. Together, these results indicate that the omega-3s in seal oil are better assimilated by the human body than those in fish oil.

 

In the same study, only seal oil was shown to decease triacylglycerol levels (elevated triacylglycerols are a risk factor for cardiovascular disease) and increase HDL (“good”) cholesterol levels. By encouraging an overall healthier plasma lipid profile, seal oil is likely more efficient than fish oil at promoting heart health and lowering the risk of blood clots.

Plan de travail 1 copie 5

10 X more effective than EPA

A study by Kanayasu-Toyoda et al.Kanayasu-Toyoda T, Morita I, Murota S. Docosapentaenoic acid (22:5, n-3), an elongation metabolite of eicosapentaenoic acid (20:5, n-3), is a potent stimulator of endothelial cell migration on pretreatment in vitro. Prostaglandins Leukot Essent Fatty Acids. 1996 May;54(5):319-25. doi: 10.1016/s0952-3278(96)90045-9. PMID: 8832760. looked at the effects of distinct omega-3s on endothelial cell migration. Endothelial cells line blood vessels and regulate exchanges between the bloodstream and neighbouring cells; endothelial cell migration plays a key role in blood vessel repair and in preventing plaque buildup in arteries.

 

The researchers treated endothelial cell with EPA and DPA separately. The EPA treatment (5.0 ug/ml) resulted in a dose dependent increase in migration response; only one-tenth the amount of DPA (0.5 ug/ml) was required to incite the same response. This indicates that DPA may be up to 10 times more effective, by concentration, than EPA at fighting artherogensis, or the formation of fatty plaques in arteries.

Boosts all key Omega-3’s

An interesting human clinical trial involved giving doses of concentrated DPA to a number of subjects. The study showed that, even after short-term supplementation with DPA, blood levels of EPA, DHA and DPA were all elevated. This study showed that unlike DPA, an EPA supplementation only increased the proportions of EPA in the body.  This indicates DPA acts as a “storage depot,” allowing the body to store and access these crucial omega-3s as needed. This optimizes absorption and utilization.Miller E, Kaur G, Larsen A, Loh SP, Linderborg K, Weisinger HS, Turchini GM, Cameron-Smith D, Sinclair AJ. A short-term n-3 DPA supplementation study in humans. Eur J Nutr. 2013 Apr;52(3):895-904. doi: 10.1007/s00394-012-0396-3. Epub 2012 Jun 23. PMID: 22729967.

 

An earlier study by Kaur et al. (2009)Kaur G, Cameron-Smith D, Garg M, Sinclair AJ. Docosapentaenoic acid (22:5n-3): a review of its biological effects. Prog Lipid Res. 2011 Jan;50(1):28-34. doi: 10.1016/j.plipres.2010.07.004. Epub 2010 Jul 23. PMID: 20655949. https://pubmed.ncbi.nlm.nih.gov/20655949/ showed that supplementing with DPA significantly raised DPA concentrations in all tissues. It also significantly increased the concentration of DHA in liver and the concentration of EPA in liver, heart and skeletal muscles.

Plan de travail 1 copie 3
Source: Miller E, Kaur G, Larsen A, Loh SP, Linderborg K, Weisinger HS, Turchini GM, Cameron-Smith D, Sinclair AJ. A short-term n-3 DPA supplementation study in humans. Eur J Nutr. 2013 Apr;52(3):895-904. doi: 10.1007/s00394-012-0396-3. Epub 2012 Jun 23. PMID: 22729967.

Data also show that DPA helps to achieve maximal endothelial migration, a critical function in repairing blood vessels.Kaur G, Cameron-Smith D, Garg M, Sinclair AJ. Docosapentaenoic acid (22:5n-3): a review of its biological effects. Prog Lipid Res. 2011 Jan;50(1):28-34. doi: 10.1016/j.plipres.2010.07.004. Epub 2010 Jul 23. PMID: 20655949 Mann NJ, O’Connell SL, Baldwin KM, Singh I, Meyer BJ. Effects of seal oil and tuna-fish oil on platelet parameters and plasma lipid levels in healthy subjects. Lipids. 2010 Aug;45(8):669-81. doi: 10.1007/s11745-010-3450-z. Epub 2010 Jul 23. PMID: 20652432.

 

The full range of health benefits of DPA are only just beginning to be understood. Studies in mammals and cell cultures have underscored its value in fighting inflammation, improving blood vessel health and elasticity, reducing the risk of blood clots, and metabolising fats.

 

The evidence is mounting, and it’s clear: DPA is a powerful omega-3 with a host of benefits and it also improves the body’s use of other essential omega-3s. Choosing fish oil, or any other omega-3 supplement without DPA, is a missed opportunity for better overall wellbeing.

Oil

Pure Omega-3 Seal Oil

Seal oil is a complete source of Omega-3 (DPA + DHA + EPA) with optimized absorption given its mammalian molecular structure.

Seal OilSeal Oil

Seal Oil

Textile

Unique Natural Fur & Leather

Seal fur and leather is a very versatile textile used in multiple applications such as accessories, footwear, outerwear and home decor.

Seal Fur & LeatherSeal Fur & Leather

Seal Fur & Leather

Meat

Wild Canadian Meat

Seal meat represents an excellent source of protein and is high in iron, zinc, magnesium and vitamin B-12. This wild game meat is free from antibiotics and added hormones.

Seal MeatSeal Meat

Seal Meat

References